منابع مشابه
A traceless vascular-targeting antibody-drug conjugate for cancer therapy.
Monoclonal antibodies have demonstrated considerable utility in the clinical treatment of cancer, but unmodified immunoglobulins are rarely curative, especially when used as single agents. Thus, there is considerable interest in arming antibodies with bioactive payloads (e.g., drugs, radionuclides, cytokines), to improve their potency and selectivity, thus increasing activity at the tumor site ...
متن کاملTargeting angiogenesis in cancer therapy.
Angiogenesis is an essential process in tumor growth. The concept of angiogenesis, when proposed by Folksman in 1971, had a great impact on cancer research and therapy, as the survival and proliferation of cancer depend on angiogenesis, which could be a target of cancer therapy. In subsequent decades, numerous antiangiogenic agents were developed, and some of them have been applied clinically. ...
متن کاملTargeting MUC16 in Cancer Therapy
Over the recent decades, there has been a number of studies investigating the role of mucins in the pathogenesis of various cancers such as breast, lung, ovarian, gastrointestinal and pancreatic malignancies. Since then, it has been discovered that mucins play a critical role in tumorigenesis as they can mediate cell proliferation, metastasis and resistance to chemotherapy. Thus, mucins have be...
متن کاملTargeting MET in cancer therapy
MET encodes a receptor tyrosine kinase c-MET for hepatocyte growth factor (HGF). The specific combination of c-MET and HGF activates downstream signaling pathways to trigger cell migration, proliferation, and angiogenesis. MET exon 14 alterations and MET gene amplification play a critical role in the origin of cancer. Several monoclonal antibodies and small-molecule inhibitors of c-MET have bee...
متن کاملTargeting cancer stem cells in cancer therapy
Cancer stem cells (CSCs) have emerged as a population of cells that plays a vital role in recurrence of metastatic cancer, particularly resistant to chemotherapy and radiotherapy. In this article, we will discuss the correlation of CSCs with tumor immunology, microenvironment, long noncoding RNAs (lncRNAs) and tumor associated genes. These particular areas of discussion may help to identify nov...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Open Schools Journal for Open Science
سال: 2020
ISSN: 2623-3606
DOI: 10.12681/osj.22596